| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
We investigated whether dorsal
hindbrain and/or peripheral cocaine- and amphetamine-regulated
transcript peptide (CARTp) acts to suppress gastric emptying of a
caloric stimulus. Furthermore, effects of dorsal hindbrain CARTp on
sucrose consumption and licking microstructure was studied, as well as
the possible contribution of corticotropin-releasing factor (CRF)
receptors to mediate effects of CARTp downstream on emptying and
sucrose intake. Rats bearing gastric fistulas received intragastric
infusions (1.0 ml/min) of 12 ml 12.5% glucose. Gastric samples were
withdrawn immediately after the intragastric infusion to reflect
emptying during gastric fill. CARTp injected in the fourth ventricle
intracerebroventricularly (0.5 and 1.0 µg) suppressed gastric
emptying. CARTp reduced sucrose intake at similar doses and altered a
variety of lick microstructure variables (no. of licks, bursts,
clusters, licks/burst, licks/clusters, interlick interval, first meal
size, and first meal duration). Pretreatment with the CRF antagonist
-helical CRF-(9-41) blocked the effect of 1.0 µg
CARTp on gastric emptying but not on sucrose consumed or on any of the
licking microstructure parameters. These data demonstrate differential
mediation of the feeding and gastric inhibitory effects of CARTp and
suggest that CARTp-induced inhibition of gastric emptying does not
contribute to this peptide's ability to inhibit food intake.
brain stem; corticotropin-releasing factor; ingestive behavior; licking microstructure
This article has been cited by other articles:
|
|
 |
|
  K. P. Skibicka, A. L. Alhadeff, and H. J. Grill Hindbrain Cocaine- and Amphetamine-Regulated Transcript Induces Hypothermia Mediated by GLP-1 Receptors J. Neurosci., May 27, 2009; 29(21): 6973 - 6981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. de Lartigue, R. Dimaline, A. Varro, and G. J. Dockray Cocaine- and Amphetamine-Regulated Transcript: Stimulation of Expression in Rat Vagal Afferent Neurons by Cholecystokinin and Suppression by Ghrelin J. Neurosci., March 14, 2007; 27(11): 2876 - 2882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Smedh and T. H. Moran The dorsal vagal complex as a site for cocaine- and amphetamine-regulated transcript peptide to suppress gastric emptying Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R124 - R130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Peptides that regulate food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1370 - R1374. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
