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Am J Physiol Regul Integr Comp Physiol 284: R1621-R1630, 2003. First published February 27, 2003; doi:10.1152/ajpregu.00572.2002
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Vol. 284, Issue 6, R1621-R1630, June 2003

The role of hypothalamic input on corticotroph maturation in fetal sheep

Sharla F. Young1, Stephen B. Tatter2, Nancy K. Valego1, Jorge P. Figueroa3, Jalonda Thompson4, and James C. Rose1,3

Departments of 1 Physiology/Pharmacology, 3 Obstetrics/Gynecology, and 2 Neurosurgery, 4 Excellence in Cardiovascular Sciences Summer Program, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157

Corticotropin-releasing hormone receptor type 1 (CRH-R1) expression1 and vasopressin type 1b (V1b) receptor protein decrease in late-gestation fetal sheep. Because hypothalamo-pituitary disconnection (HPD) has been demonstrated to prevent the morphological maturation of corticotrophs, we hypothesized that hypothalamic input is necessary for the maturational changes in CRH-R1 and V1b receptor levels. We measured CRH-R1 and V1b receptor expression in the anterior pituitaries of fetuses at 140 days gestational age (dGA) that underwent HPD or sham surgery at 120 dGA. CRH-R1 mRNA decreased similarly in HPD and sham-operated fetuses compared with 120 dGA naive fetuses. However, CRH-R1 protein levels were elevated in HPD fetuses compared with sham and were not different from 120 dGA values. V1b protein levels decreased similarly in HPD and sham-operated fetuses compared with 120 dGA naive fetuses. We conclude that hypothalamic input to the pituitary is necessary for the decrease in CRH-R1 receptor protein levels in late-gestation fetal sheep. However, hypothalamic input is not necessary for the decrease in V1b receptor expression seen in late gestation.

corticotropin-releasing hormone; arginine vasopressin; corticotropin-releasing hormone receptor; vasopressin receptor; hypothalamo-pituitary disconnection

1 In the manuscript, expression is used to indicate parallel changes in protein and mRNA.




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