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Am J Physiol Regul Integr Comp Physiol 285: R1116-R1123, 2003. First published July 31, 2003; doi:10.1152/ajpregu.00166.2002
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INFLAMMATION, CYTOKINES, AND TEMPERATURE REGULATION

Brain regions expressing Fos during thermoregulatory behavior in rats

Megumi Maruyama,1 Maiko Nishi,1 Masahiro Konishi,1 Yuko Takashige,1 Kei Nagashima,1 Toshikazu Kiyohara,2 and Kazuyuki Kanosue1

1Department of Physiology, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Osaka 565-0871; and 2Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan

Submitted 14 March 2002 ; accepted in final form 14 July 2003

We surveyed the neural substrata for behavioral thermoregulation with immunohistochemical analysis of the expression of Fos protein in the rat brain. We used an operant system in which a rat exposed to heat (40°C) could get cold air (0°C) for 30 s when it moved into the reward area. Rats moved in and out of the reward area of the system periodically and thus maintained their body temperature at a normal level. In the rats performing heat escape behavior (active group), strong Fos immunoreactivity (Fos-IR) was found in the median preoptic nucleus (MnPO), parastrial nucleus (PS), and dorsomedial hypothalamus (DMH) compared with the controls. Another group of rats (passive group) were given the same temperature changes, regardless of the rat's movement, as those obtained by rats of the active group. Fos-IR in the MnPO was also seen in this group. The present results suggest that the PS and DMH play an important role in the genesis of thermoregulatory behavior, whereas the MnPO may be important for detecting changes in ambient and/or body temperatures.

preoptic area; dorsomedial hypothalamus; operant behavior


Address for reprint requests and other correspondence: K. Kanosue, School of Sport Sciences, Waseda University, Mikajima 2-579-15, Tokorozawa, Saitama 359-1192, Japan (E-mail: kanosue{at}waseda.jp).




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