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Am J Physiol Regul Integr Comp Physiol 285: R1496-R1503, 2003. First published August 21, 2003; doi:10.1152/ajpregu.00183.2003
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NEUROHUMORAL CONTROL OF CIRCULATION AND HYPERTENSION

Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats

Phouangmala Scruggs, Siok L. Dun, and Nae J. Dun

Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614

Submitted 7 April 2003 ; accepted in final form 11 August 2003

The present study was undertaken to investigate the origin of cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactive (irCART) fibers observed in the nucleus of the solitary tract (NTS) and assess the role of CART peptide on phenylephrine (PE)-induced baroreflex. Immunohistochemical and retrograde tract-tracing studies showed that some of the irCART fibers observed in the NTS may have their cell bodies in the nodose ganglia. In urethane-anesthetized rats, intracisternal or bilateral intra-NTS microinjection of the CART peptide fragment 55-102 (0.1-3 nmol), referred to herein as CARTp, consistently and dose dependently attenuated PE-induced bradycardia. CARTp, in the doses used here, caused no significant changes of resting blood pressure or heart rate. Bilateral intra-NTS injections of CART antibody (1:500) potentiated PE-induced bradycardia. Injections of saline, normal rabbit serum, or concomitant injection of CARTp and CART antiserum into the NTS caused no significant changes of PE-induced baroreflex. The result suggests that endogenously released CARTp from primary afferents or exogenously administered CARTp modulates PE-induced baroreflex.

baroreceptor reflex; nodose ganglia; nucleus tractus solitarius; phenylephrine


Address for reprint requests and other correspondence: N. J. Dun, Dept. of Pharmacology, James H. Quillen College of Medicine, East Tennessee State Univ., PO Box 70577, Johnson City, TN 37614 (E-mail: dunnae{at}mail.etsu.edu).






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