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NEUROHUMORAL CONTROL OF CIRCULATION AND HYPERTENSION

Differential control over postganglionic neurons in rat cardiac ganglia by NA and DmnX neurons: anatomical evidence

¹Departments of Pediatric, Kosair Children's Hospital Research Institute and Departments of ²Physiology and Biophysics and ⁴Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202; and ³Department of Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153

Submitted 21 March 2003 ; accepted in final form 17 November 2003

In previous single-labeling experiments, we showed that neurons in the nucleus ambiguus (NA) and the dorsal motor nucleus of the vagus (DmnX) project to intrinsic cardiac ganglia. Neurons in these two motor nuclei differ significantly in the size of their projection fields, axon caliber, and endings in cardiac ganglia. These differences in NA and DmnX axon cardiac projections raise the question as to whether they target the same, distinct, or overlapping populations of cardiac principal neurons. To address this issue, we examined vagal terminals in cardiac ganglia and tracer injection sites in the brain stem using two different anterograde tracers {1,1'-dioleyl-3,3,3',3'-tetramethylindocarbocyanine methanesulfonate and 4-[4-(dihexadecylamino)-styryl]-N-methylpyridinium iodide} and confocal microscopy in male Sprague-Dawley rats. We found that 1) NA and DmnX neurons innervate the same cardiac ganglia, but these axons target separate subpopulations of principal neurons and 2) axons arising from neurons in the NA and DmnX in the contralateral sides of the brain stem enter the cardiac ganglionic plexus through separate bundles and preferentially innervate principal neurons near their entry regions, providing topographic mapping of vagal motor neurons in left and right brain stem vagal nuclei. Because the NA and DmnX project to distinct populations of cardiac principal neurons, we propose that they may play different roles in controlling cardiac function.

brain stem; parasympathetic; anterograde tracing; heart; baroreflex

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