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Am J Physiol Regul Integr Comp Physiol 287: R1012-R1013, 2004; doi:10.1152/classicessays.00011.2004
0363-6119/04 $5.00

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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Hypothalamic control of body temperature: insights from the past

John B. Pierce Laboratory and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06519

ABSTRACT

This essay looks at the historical significance of three APS classic papers that are freely available online:

Hammel HT, Hardy JD, and Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol 198: 481-486, 1960 (http://ajplegacy.physiology.org/cgi/reprint/198/3/481).

Hammel HT, Jackson DC, Stolwijk JAJ, Hardy JD, and Strømme SB. Temperature regulation by hypothalamic proportional control with an adjustable set point. J Appl Physiol 18: 1146-1154, 1963 (http://jap.physiology.org/cgi/reprint/18/6/1146).

Hellstrøm B and Hammel HT. Some characteristics of temperature regulation in the unanesthetized dog. Am J Physiol 213: 547-556, 1967 (http://ajplegacy.physiology.org/cgi/reprint/213/2/547).