HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 287/6/R1450    most recent 00215.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Edsbagge, M. Articles by Wikkelso, C. Search for Related Content PubMed PubMed Citation Articles by Edsbagge, M. Articles by Wikkelso, C.

ENVIRONMENTAL, EXERCISE AND RESPIRATORY PHYSIOLOGY

Spinal CSF absorption in healthy individuals

¹Hydrocephalus Research Unit, Institute of Clinical Neuroscience and ²Department of Radiophysics, Sahlgrenska University Hospital, Göteborg University, S-413 45 Göteborg, Sweden

Submitted 31 March 2004 ; accepted in final form 10 August 2004

The present study examines the extent of spinal cerebrospinal fluid (CSF) absorption in healthy individuals in relation to physical activity, CSF production, intracranial pressure (ICP), and spinal CSF movement. Thirty-four healthy individuals aged 21–35 yr were examined by lumbar puncture and radionuclide cisternography with repeated imaging. ICP was registered before and after CSF drainage, and CSF production was calculated. Spinal CSF absorption was calculated as reduction in spinal radionuclide activity. The radionuclide activity in the spinal subarachnoidal space was gradually decreased by 20 ± 13% (mean ± SD) during 1 h. The reduction was higher in active than in resting individuals (27 ± 12% vs. 13 ± 9%). The mean ICP in 19 of the individuals was 13.6 ± 3.1 cmH₂O. B-waves were found in 79% of the individuals, with a mean frequency of 0.6 ± 0.3 min^–1. The mean CSF production rate was 0.34 ± 0.13 ml/min. There were no correlations between radionuclide reduction, spinal movement of the radionuclide, and CSF production rate. The spinal radionuclide reduction found in this study indicates a spinal CSF absorption of 0.11–0.23 ml/min, more pronounced in active than in resting individuals.

arachnoid villi; cerebrospinal fluid spinal flow; cerebrospinal fluid production; cerebrospinal fluid pressure; radionuclide imaging

This article has been cited by other articles:

				J. Malm and A. Eklund Idiopathic normal pressure hydrocephalus Practical Neurology, February 1, 2006; 6(1): 14 - 27. [Full Text] [PDF]