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Am J Physiol Regul Integr Comp Physiol 288: R531-R538, 2005. First published September 16, 2004; doi:10.1152/ajpregu.00158.2004
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COMPARATIVE AND EVOLUTIONARY PHYSIOLOGY

AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila

Guillaume Isabel,1,2 Jean-René Martin,3 Saad Chidami,1 Jan A. Veenstra,1,4 and Philippe Rosay1,4

1Laboratoire de Neuroendocrinologie des Insectes and 4Laboratoire des Neurosciences Cognitives, Unité Mixte de Recherche 5106 Centre National de la Recherche Scientifique (CNRS)/Université Bordeaux I Avenue des Facultés, Talence Cedex; 3Bases Neurales du Mouvement chez la Drosophile, Laboratoire de Neurobiologie de l’Apprentissage, de la Mémoire, et de la Communication, Unité Mixte de Recherche 8620 CNRS/Université Paris sud, Orsay; and 2Développement, Evolution, Plasticité du Système Nerveux, CNRS, Gif-sur-Yvette, France

Submitted 10 March 2004 ; accepted in final form 14 September 2004

Adipokinetic hormone (AKH) is a metabolic neuropeptide principally known for its mobilization of energy substrates, notably lipid and trehalose during energy-requiring activities, such as flight and locomotion. Drosophila melanogaster AKH cell localization in corpora cardiaca, as in other insect species, was confirmed by immunoreactivity and by a genetic approach using the UAS/GAL4 system. To assess AKH general physiological rules, we ablated AKH endocrine cells by specifically driving the expression of apoptosis transgenes in AKH cells. Trehalose levels were decreased in larvae and starved adults, when the stimulation by AKH of the production of trehalose from fat body glycogen is no longer possible. Moreover, we show that these adults without AKH cells become progressively hypoactive. Finally, under starvation conditions, those hypoactive AKH-knockout cell flies survived ~50% longer than control wild-type flies, suggesting that the slower rate at which AKH-ablated flies mobilize their energy resources extends their survival.

adipokinetic hormone; trehalose; locomotion; starvation; life span


Address for reprint requests and other correspondence: P. Rosay, Laboratoire des Neurosciences Cognitives, Unité Mixte de Recherche 5106 CNRS/Université Bordeaux I Av. des Facultés, F-33405 Talence Cedex, France (E-mail: p.rosay{at}lnc.u-bordeaux1.fr)




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