HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 288/5/R1325    most recent 00320.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Héliès-Toussaint, C. Articles by Grynberg, A. Search for Related Content PubMed PubMed Citation Articles by Héliès-Toussaint, C. Articles by Grynberg, A.

NEUROHUMORAL CONTROL OF CARDIOVASCULAR FUNCTION

Aortic banding in rat as a model to investigate malnutrition associated with heart failure

¹INRA-UR 1154, Lipides membranaires et Fonctions Cardiovasculaires, Faculté de pharmacie, Châtenay-Malabry, and ²Laboratoire de Biologie de la Nutrition, EA 2498, Faculté de pharmacie, Paris, France

Submitted 14 May 2004 ; accepted in final form 17 December 2004

Heart failure is a severe pathology, which has displayed a dramatic increase in the occurrence of patients with chronic heart disease in developed countries, as a result of increases in the population's average age and in survival time. This pathology is associated with severe malnutrition, which worsens the prognosis. Although the cachexia associated with chronic heart failure is a well-known complication, there is no reference animal model of malnutrition related to heart failure. This study was designed to evaluate the nutritional status of rats in a model of loss of cardiac function obtained by ascending aortic banding. Cardiac overload led to the development of cardiac hypertrophy, which decompensates to heart failure, with increased brain natriuretic peptide levels. The rats displayed hepatic dysfunction and an associated renal hypotrophy and renal failure, evidenced by the alteration in renal function markers such as citrullinemia, creatininemia, and uremia. Malnutrition has been evidenced by the alteration of protein and amino acid metabolism. A muscular atrophy with decreased protein content and increased amino acid concentrations in both plasma and muscle was observed. These rats with heart failure displayed a multiorgan failure and malnutrition, which reflected the clinical situation of human chronic heart failure.

cachexia; multi-organ failure; amino acids