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Regulation of Lipid Metabolism and of Insulin Sensitivity by PPARs

Hepatic -oxidation and carnitine palmitoyltransferase I in neonatal pigs after dietary treatments of clofibric acid, isoproterenol, and medium-chain triglycerides

¹Department of Animal Science, ²Interdepartmental Nutrition Program, and ³Functional Genomics Program, North Carolina State University, Raleigh, NC

Submitted 3 December 2004 ; accepted in final form 21 February 2005

A suckling piglet model was used to study nutritional and pharmacologic means of stimulating hepatic fatty acid -oxidation. Newborn pigs were fed milk diets containing either long- or medium-chain triglycerides (LCT or MCT). The long-chain control diet was supplemented further with clofibric acid (0.5%) or isoproterenol (40 ppm), and growth was monitored for 10–12 days. Clofibrate increased rates of hepatic peroxisomal and mitochondrial -oxidation of [1-¹⁴C]-palmitate by 60 and 186%, respectively. Furthermore, malonyl-CoA sensitive carnitine palmitoyltransferase (CPT I) activity increased 64% (P < 0.05) in pigs receiving clofibrate. Increased CPT I activity was not congruent with changes in message, as elevated abundance of CPT I mRNA was not detected (P = 0.16) when assessed by qRT-PCR. Neither rates of -oxidation nor CPT activities were affected by dietary MCT or by isoproterenol treatment (P > 0.1). Collectively, these findings indicate that clofibrate effectively induced hepatic CPT activity concomitant with increased fatty acid -oxidation.

acyl-CoA oxidase; fatty acid oxidase; malonyl-CoA; peroxisome; peroxisome proliferator-activated receptor

This article has been cited by other articles:

				S. Luci, B. Giemsa, H. Kluge, and K. Eder Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R70 - R77. [Abstract] [Full Text] [PDF]

				P. Lyvers Peffer, X. Lin, S. K. Jacobi, L. A. Gatlin, J. Woodworth, and J. Odle Ontogeny of Carnitine Palmitoyltransferase I Activity, Carnitine-Km, and mRNA Abundance in Pigs throughout Growth and Development J. Nutr., April 1, 2007; 137(4): 898 - 903. [Abstract] [Full Text] [PDF]