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This Article Full Text Full Text (PDF) All Versions of this Article: 289/6/R1703    most recent 00773.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Tsubone, T. Articles by Yoshimatsu, H. Search for Related Content PubMed PubMed Citation Articles by Tsubone, T. Articles by Yoshimatsu, H.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Leptin downregulates ghrelin levels in streptozotocin-induced diabetic mice

Department of Internal Medicine 1, Faculty of Medicine, Oita University, Hasama, Oita, Japan

Submitted 4 November 2004 ; accepted in final form 9 August 2005

Ghrelin, an orexigenic peptide produced in the stomach, is increased in streptozotocin (STZ)-induced diabetic (DM) mice. This study clarifies the regulation of ghrelin levels by leptin in STZ-DM mice. STZ-DM mice had higher plasma ghrelin concentrations and greater ghrelin mRNA expression than control mice. Changes in ghrelin levels were dose dependently attenuated by the subcutaneous injection of leptin (0–27 nmol·kg^–1·day^–1 over 7 days). Leptin treatment also partially reversed the hyperphagia and hyperglycemia observed in STZ-DM mice, but not the hypoinsulinemia, and there was a decrease in plasma ghrelin concentrations and ghrelin mRNA levels compared with STZ-LEP pair-fed mice. These results indicate that leptin treatment partially reverses elevated plasma ghrelin levels in STZ-DM mice independent of food intake and insulin, and suggest that hypoleptinemia in STZ-DM mice upregulates ghrelin.

diabetes mellitus; neuropeptide Y