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Am J Physiol Regul Integr Comp Physiol 290: R819-R825, 2006. First published October 13, 2005; doi:10.1152/ajpregu.00602.2005
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DEVELOPMENTAL PHYSIOLOGY AND PREGNANCY

Iris movement mediates vascular apoptosis during rat pupillary membrane regression

Yuki Morizane,1,2 Satoshi Mohri,2 Jun Kosaka,3 Shigenobu Toné,4 Takahiko Kiyooka,2 Takehiro Miyasaka,2 Juichiro Shimizu,2 Yasuo Ogasawara,5 Fumio Shiraga,6 Yohsuke Minatogawa,4 Junzo Sasaki,3 Hiroshi Ohtsuki,1 and Fumihiko Kajiya1,2,5

1Departments of Ophthalmology, 2Cardiovascular Physiology, and 3Cytology and Histology, Okayama University Graduate School, Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;4Departments of Biochemistry and 5Medical Engineering, Kawasaki Medical School Okayama, Japan; and 6Department of Ophthalmology, Kagawa University Faculty of Medicine Kagawa, Japan

Submitted 19 August 2005 ; accepted in final form 7 October 2005

In the course of mammalian lens development, a transient capillary meshwork known as the pupillary membrane (PM) forms, which is located at the pupil area; the PM nourishes the anterior surface of the lens and then regresses to make the optical path clear. Although the involvement of apoptotic process has been reported in the PM regression, the initiating factor remains unknown. We initially found that regression of the PM coincided with the development of iris motility, and iris movement caused cessation and resumption of blood flow within the PM. Therefore, we investigated whether the development of the iris's ability to constrict and dilate functions as an essential signal that induces apoptosis in the PM. Continuous inhibition of iris movement with mydriatic agents from postnatal day 7 to day 12 suppressed apoptosis of the PM and migration of macrophage toward the PM, and resulted in the persistence of PM in rats. The distribution of apoptotic cells in the regressing PM was diffuse and showed no apparent localization. These results indicated that iris movement induced regression of the PM by changing the blood flow within it. This study suggests the importance of the physiological interactions between tissues—in this case, the iris and the PM—as a signal to advance vascular regression during organ development, and defines a novel function of the iris during ocular development in addition to the well-known function, that is, optimization of light transmission into the eye.

ocular development; miosis; mydriasis; microcirculation


Address for reprint requests and other correspondence: Y. Morizane, 2–5-1 Shikata-cho Okayama City, Okayama, 700–8558, Japan (e-mail: zanetbb{at}ybb.ne.jp)






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