HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 292/6/R2174    most recent 00032.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Begg, D. P. Articles by Mathai, M. L. Search for Related Content PubMed PubMed Citation Articles by Begg, D. P. Articles by Mathai, M. L.

INFLAMMATION AND CYTOKINES

Suppression of endotoxin-induced fever in near-term pregnant rats is mediated by brain nitric oxide

¹School of Psychological Science, La Trobe University, Bundoora, Victoria; and ²Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Victoria, Australia

Submitted 17 January 2007 ; accepted in final form 27 February 2007

Over the last three decades, experiments in several mammalian species have shown that the febrile response to bacterial endotoxin is attenuated late in pregnancy. More recent evidence has established that the expression of nitric oxide synthase (NOS) enzymes is increased in the brain late in pregnancy. The current study investigated the possible role of brain nitric oxide in mediating the phenomenon of fever suppression. Core body temperature (T_b) of near-term pregnant rats (day 19 and 20) was measured following inhibition of brain NOS and intraperitoneal injection of LPS (50 µg/kg); they were compared with both day 15 pregnant and virgin animals. Intracerebroventricular injection with an inhibitor of NOS, N^G-monomethyl-L-arginine citrate (L-NMMA; 280 µg), in near-term pregnant rats restored the febrile response to LPS. As expected, near-term dams that received intracerebroventricular vehicle + IP LPS did not increase T_b, in contrast to the 1.0 ± 0.2°C rise in T_b in dams treated with ICV L-NMMA + IP LPS (P < 0.01). In virgin females and day 15 pregnant controls receiving this treatment, the increases in T_b were 1.5 ± 0.3°C and 1.6 ± 0.4°C, respectively. Thus, blockade of brain NOS restored the febrile response to LPS in near-term dams; at 5 h postinjection, T_b was 60–70% of that observed in virgins and day 15 pregnant animals. Intracerebroventricular L-NMMA alone did not induce a significant change in T_b in any group. These results suggest that the mechanism underlying the suppression of the febrile response in near-term pregnancy is mediated by nitric oxide signaling in the brain.

nitric oxide synthase; N^G-monomethyl-L-arginine citrate; lipopolysaccharide; core body temperature; thermoregulation

This article has been cited by other articles:

				S. J. Spencer, A. Mouihate, M. A. Galic, and Q. J. Pittman Central and peripheral neuroimmune responses: hyporesponsiveness during pregnancy J. Physiol., January 15, 2008; 586(2): 399 - 406. [Abstract] [Full Text] [PDF]

				A. Aguilar-Valles, S. Poole, Y. Mistry, S. Williams, and G. N. Luheshi Attenuated fever in rats during late pregnancy is linked to suppressed interleukin-6 production after localized inflammation with turpentine J. Physiol., August 15, 2007; 583(1): 391 - 403. [Abstract] [Full Text] [PDF]