HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 293/1/R267    most recent 00071.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Gutkowska, J. Articles by Jankowski, M. Search for Related Content PubMed PubMed Citation Articles by Gutkowska, J. Articles by Jankowski, M.

NEUROHUMORAL CONTROL OF CARDIOVASCULAR FUNCTION

Effect of exercise training on cardiac oxytocin and natriuretic peptide systems in ovariectomized rats

¹Laboratory of Cardiovascular Biochemistry, Research Centre, Centre Hospitalier de l'Université de Montréal-Hôtel-Dieu, and Department of Medicine, Université de Montréal; and ²Department of Kinesiology, Université de Montréal, Montréal, Québec, Canada

Submitted 31 January 2007 ; accepted in final form 25 April 2007

Exercise training results in cardiovascular and metabolic adaptations that may be beneficial in menopausal women by reducing blood pressure, insulin resistance, and cholesterol level. The adaptation of the cardiac hormonal systems oxytocin (OT), natriuretic peptides (NPs), and nitric oxide synthase (NOS) in response to exercise training was investigated in intact and ovariectomized (OVX) rats. Ovariectomy significantly augmented body weight (BW), left ventricle (LV) mass, and intra-abdominal fat pad weight and decreased the expression of oxytocin receptor (OTR), atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and guanylyl cyclase-A (GC-A), in the right atrium (RA) and LV, indicating estrogenic control of these genes. These effects of ovariectomy were counteracted by 8-wk-long exercise training which decreased fat pad weight (33.4 ± 2.3 to 23.4 ± 3.1 g, n = 8, P < 0.05), plasma free fatty acids (0.124 ± 0.033 to 0.057 ± 0.010 mM, n = 8, P < 0.01), and plasma triacylglycerol (0.978 ± 0.174 to 0.588 ± 0.115 mM, n = 8, P < 0.05). Chronic exercise tended to decrease BW and stimulated ANP (4- to 5-fold) and OTR gene expression in the LV and RA and BNP and inducible NOS (iNOS) mRNA in the LV. In sham-operated rats, exercise augmented ANP expression in the RA, downregulated GC-A mRNA in the LV and RA, but increased its expression threefold in the RA of OVX animals. Endothelial NOS and iNOS expression was enhanced in the left atrium of sham-operated rats. Altogether, these data indicate that in OVX animals, chronic exercise significantly enhances cardiac OT, NPs, and NOS, thus implicating all three hormonal systems in the beneficial effects of exercise training.

heart; atrial natriuretic peptide; ovariectomy

This article has been cited by other articles:

				J. Gutkowska, T. L. Broderick, D. Bogdan, D. Wang, J.-M. Lavoie, and M. Jankowski Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy J. Physiol., October 1, 2009; 587(19): 4725 - 4736. [Abstract] [Full Text] [PDF]