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Am J Physiol Regul Integr Comp Physiol 293: R956-R960, 2007. First published May 30, 2007; doi:10.1152/ajpregu.00111.2007
0363-6119/07 $8.00
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WATER AND ELECTROLYTE HOMEOSTASIS

A PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17beta

Juan Fuentes, Pedro M. Guerreiro, Teresa Modesto, Josep Rotllant, Adelino V. M. Canario, and Deborah M. Power

Centro de Ciências do Mar, CIMAR-Laboratório Associado, Universidade do Algarve, Campus de Gambelas, Faro, Portugal

Submitted 14 February 2007 ; accepted in final form 21 May 2007

Estradiol (E2) increases circulating calcium and phosphate levels in fish, thus acting as a hypercalcemic and hyperphosphatemic factor during periods of high calcium requirements, such as during vitellogenesis. Since parathyroid hormone (PTH)-related protein (PTHrP) has been shown to be calciotropic in fish, we hypothesized that the two hormones could be mediating the same process. Sea bream (Sparus auratus) juveniles receiving a single intraperitoneal injection of piscine PTHrP(1-34) showed an elevation in calcium plasma levels within 24 h. In contrast, injections of the PTH/PTHrP receptor antagonist PTHrP(7-34) decreased circulating levels of calcium in the same period. Intraperitoneal implants of estradiol-17beta (E2; 10 µg/g) evoked significant increases of circulating plasma levels of calcium and phosphorus and a sustained increases of circulating plasma levels of PTHrP. However, a combined treatment of E2 and PTHrP(7-34) evoked a markedly lower calcium response compared with E2 alone. We conclude that PTHrP or a related peptide that binds the PTH/PTHrP receptor mediates, at least in part, the hypercalcemic effect of E2 in calcium and phosphate balance in fish.

fish; calcium; phosphate


Address for reprint requests and other correspondence: Juan Fuentes, Centro de Ciências do Mar, CIMAR-Laboratório Associado, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal (e-mail: jfuentes{at}ualg.pt)






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