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APPETITE, OBESITY, DIGESTION, AND METABOLISM

Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs

¹Veterans Research Foundation and ²Transtimulation Research Incorporated, Oklahoma City, Oklahoma; and ³Division of Gastroenterology, University of Texas Medical Branch at Galveston, Galveston, Texas

Submitted 21 November 2006 ; accepted in final form 14 September 2007

The aim of this study was to determine the effects and mechanism of synchronized gastric electrical stimulation (SGES) on gastric contractions and gastric emptying. The first experiment was designed to study the effects of SGES on antral contractions in four randomized sessions. Sessions 1 (control) and 2 (atropine) were performed in the fasting state, composed of three 30-min periods (baseline, stimulation, and recovery). Sessions 3 (control) and 4 (SGES performed during 2nd 20-min period) were performed in the fed state, consisting of two 20-min periods; glucagon was injected after the first 20-min recording. The second experiment was designed to study the effect of SGES on gastric emptying and consisted of two sessions (control and SGES). SGES was delivered with train duration of 0.5–0.8s, pulse frequency of 40 Hz, width of 2 ms, and amplitude of 4 mA. We found that 1) SGES induced gastric antral contractions in the fasting state. The motility index was 1.3 ± 0.5 at baseline and 6.1 ± 0.7 (P = 0.001) during SGES. This excitatory effect was completely blocked by atropine. 2) SGES enhanced postprandial antral contractions impaired by glucagon. 3) SGES significantly accelerated glucagon-induced delayed gastric emptying. Gastric emptying was 25.5 ± 11.3% without SGES and 38.3 ± 10.7% with SGES (P = 0.006 vs. control). This novel method of SGES induces gastric antral contractions in the fasting state, enhances glucagon-induced antral hypomotility in the fed state, and accelerates glucagon-induced delayed gastric emptying. The effect of SGES on antral contractions is mediated via the cholinergic pathway.

gastric electrical stimulation; gastroparesis; gastric emptying; gastrointestinal motility

This article has been cited by other articles:

				J. Chen, T. Koothan, and J. D. Z. Chen Synchronized gastric electrical stimulation improves vagotomy-induced impairment in gastric accommodation via the nitrergic pathway in dogs Am J Physiol Gastrointest Liver Physiol, February 1, 2009; 296(2): G310 - G318. [Abstract] [Full Text] [PDF]

				J. Yin and J. D. Chen Excitatory effects of synchronized intestinal electrical stimulation on small intestinal motility in dogs Am J Physiol Gastrointest Liver Physiol, December 1, 2007; 293(6): G1190 - G1195. [Abstract] [Full Text] [PDF]