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Am J Physiol Regul Integr Comp Physiol 293: R2210-R2217, 2007. First published September 26, 2007; doi:10.1152/ajpregu.00615.2007 Free Article
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INFLAMMATION AND CYTOKINES

Leukocytes of exceptionally old persons display ultra-short telomeres

M. Kimura,1,* M. Barbieri,2,* J. P. Gardner,1 J. Skurnick,1 X. Cao,1 N. van Riel,3 M. R. Rizzo,2 G. Paoliso,3 and A. Aviv1

1Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey; 2Department of Geriatric Medicine and Metabolic Diseases, Second University of Naples, Naples, Italy; and 3Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands

Submitted 24 August 2007 ; accepted in final form 20 September 2007

With a view to understanding the association between leukocyte telomere length and the human lifespan, we performed genome-wide telomere length analyses by the terminal restriction fragment length (TRFL) and single molecule telomere length analysis (STELA) of the X and Y chromosomes in leukocytes of exceptionally old (aged 90–104 yr) and younger (aged 23–74 yr) individuals. We found that the mean TRFL of 82 exceptionally old individuals was within a range projected by age-dependent TRFL attrition of 99 younger individuals. However, compared with the younger individuals, exceptionally old persons exhibited peaking of the TRFL distribution with overrepresentation of ultra-short telomeres. These findings were confirmed by the STELA. Women had longer mean TRFL than men (6.10 vs. 5.86 kb), and exceptionally old women exhibited fewer ultra-short telomeres than exceptionally old men. Our results have implications for gerontological studies of the limitation of lifespan in humans.

aging; centenarians; mortality; replication; lifespan; senescence


Address for reprint requests and other correspondence: M. Kimura, Center of Human Development and Aging, Room F-464, MSB, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Ave., Newark, New Jersey 07103 (e-mail: kimurama{at}umdnj.edu)




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M. Kimura, J. v. B. Hjelmborg, J. P. Gardner, L. Bathum, M. Brimacombe, X. Lu, L. Christiansen, J. W. Vaupel, A. Aviv, and K. Christensen
Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins
Am. J. Epidemiol., April 1, 2008; 167(7): 799 - 806.
[Abstract] [Full Text] [PDF]


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