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Am J Physiol Regul Integr Comp Physiol 294: R1996-R2000, 2008. First published April 2, 2008; doi:10.1152/ajpregu.00393.2006
0363-6119/08 $8.00
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WATER AND ELECTROLYTE HOMEOSTASIS

Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Atsushi Numata, Tatsuya Iwata, Hiromichi Iuchi, Narumi Taniguchi, Masafumi Kita, Naoki Wada, Yuji Kato, and Hidehiro Kakizaki

Department of Urology-Asahikawa Medical College, Asahikawa, Japan

Submitted 6 June 2006 ; accepted in final form 20 March 2008

The periaqueductal gray (PAG) of the mesencephalon has been implicated to be involved in the control of micturition. We investigated the micturition-suppressing region in the PAG of the cat. Decerebrated 27 adult cats were used. A microelectrode was inserted stereotaxically into the PAG, and a region was searched where electrical stimulation suppressed isovolumetric bladder contractions. Simultaneous stimulation of the pontine micturition center (PMC) and micturition-suppressing region in the PAG was performed before and after an injection of bicuculline (GABAA blocker) into the PMC. The micturition-suppressing region was found at the dorsolateral margin of the rostral PAG. Bladder contractions were not provoked by simultaneous stimulation of the PMC and micturition-suppressing region in the PAG. However, after bicuculline injection into the PMC, partial bladder contractions were provoked by simultaneous stimulation of the PMC and the micturition-suppressing region in the PAG. These results suggest that the dorsolateral margin of the rostral PAG includes the micturition-suppressing region that seems to have neural connections with the PMC. GABA is assumed to be one of the neurotransmitters that are involved in the PMC inhibition from the micturition-suppressing region in the PAG.

urination; bladder; mesencephalon


Address for reprint requests and other correspondence: A. Numata, Dept. of Urology, Asahikawa Medical College, Midorigaoka higashi 2-1-1-1, Asahikawa 078-8510, Japan (e-mail: anuma{at}asahikawa-med.ac.jp)






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