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This Article Full Text Full Text (PDF) All Versions of this Article: 295/2/R478    most recent 00176.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Polakof, S. Articles by Soengas, J. L. Search for Related Content PubMed PubMed Citation Articles by Polakof, S. Articles by Soengas, J. L.

ENDOCRINE PHYSIOLOGY AND METABOLISM

Dietary carbohydrates induce changes in glucosensing capacity and food intake of rainbow trout

Laboratorio de Fisioloxía Animal, Facultade de Bioloxía, Departamento de Bioloxía Funcional e Ciencias da Saúde, Universidade de Vigo, Vigo, Spain

Submitted 10 March 2008 ; accepted in final form 4 June 2008

We hypothesize that variations in dietary carbohydrate levels produce changes in glucosensor parameters in previously characterized glucosensing areas (hypothalamus and hindbrain) related with the regulation of food intake of a carnivorous fish species like rainbow trout. Therefore, we fed trout with standard, carbohydrate-free (CF) or high-carbohydrate (HC) diets for 10 days to assess changes in glucosensing system and food intake. Fish fed CF diet displayed hypoglycemia and increased food intake. Fish fed a HC diet displayed hyperglycemia and decreased food intake. Changes in food intake due to dietary carbohydrates were accompanied in hypothalamus and hindbrain of fish fed with HC diet by changes in parameters involved in glucosensing, such as increased glucose, glucose 6-phosphate, and glycogen levels and increased glucokinase (GK), glycogen synthase, and pyruvate kinase activities as well as increased GK and GLUT2 expression. All those results address for the first time in fish, despite the relative intolerance to glucose of carnivorous species, that dietary carbohydrates are important regulators of the glucosensing system in carnivorous fish, suggesting that the information generated by this system can be associated with the changes observed in food intake.

rainbow trout; glucosensor; food intake; hypothalamus; hindbrain

This article has been cited by other articles:

				S. Polakof, S. Panserat, E. Plagnes-Juan, and J. L. Soengas Altered dietary carbohydrates significantly affect gene expression of the major glucosensing components in Brockmann bodies and hypothalamus of rainbow trout Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1077 - R1088. [Abstract] [Full Text] [PDF]