Regulatory, Integrative and Comparative Physiology

In this Issue

January 2008; volume 294, issue 1

Cover image

Cover: Representative sections showing merged smooth muscle myosin (FITC), 5-bromo-2′-deoxyuridine (BrdU) uptake (Texas Red), and nuclei stained with 4,6-diamidino-2-phenylindole (magnification, ×200). Pink nuclei reflect those nuclei undergoing DNA synthesis as opposed to those staining a pure blue, which have been quiescent. With partial bladder outlet obstruction (pBOO), there is a marked increase in DNA synthesis within the urothelium and the serosal edges. The overwhelming preponderance of nuclei seen within the green-staining smooth muscle bundles are blue. Pink nuclei predominated between the smooth muscle bundles. Shown is a section taken following pBOO from a sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) (+/-) mouse. The preference of BrdU uptake by the nonsmooth muscle cell population was the same when compared with (+/+) and (+/-) populations. Am J Physiol Regul Integr Comp Physiol doi:10.1152/ ajpregu.00477.2007.