Percentage of plasma free fatty acid (FFA) uptake oxidized during basal and exercise (50% maximum O2 consumption). *Significantly decreased in extremely obese and extremely obese subjects after weight reduction (weight-reduced) compared with lean (P < 0.05). From Thyfault et al. (48).
Decrement in fatty acid oxidation (FAO) with obesity as indicated by various methodologies used in our laboratory. Data are redrawn from Refs. 17, 22, 23, 28, 48. *Significantly different (P ≤ 0.05) from lean controls for the listed method.
Fatty acid partitioning [labeled oleate incorporation into triacylglycerol (TAG) divided by FAO] in myotubes cultured from skeletal muscle samples obtained from lean and obese donors (23). An increased fatty acid partitioning ratio indicates preferential portioning toward storage within the muscle cell as opposed to oxidation. The positive relationship between the FAO partitioning index of the myotubes and the body mass index of the donor was statistically significant (r2 = 0.66, P < 0.001). HSkMC, human skeletal muscle cell culture method.