A: percent change in body weight during 4 wk of 30% calorie restriction and 4 wk of 60% calorie restriction. Weight for each monkey was normalized to its body weight at the beginning of the study (week 0). B: percent change in activity measured by accelerometer during the periods of 30 and 60% calorie restriction, compared with week 0. *Significant change from baseline, P ≤ 0.05.
A: total metabolic rate, measured across a 24-h day in each monkey at baseline (solid bar) and at the end of the 8-wk diet period (open bar). The mean decrease in metabolic rate from the beginning to end of the diet period was 68 kcal. B: activity-associated energy expenditure measured across a 24-h day in each monkey at baseline (solid bar) and at the end of the 8-wk diet period (open bar). The mean decrease in activity-associated energy expenditure was 41 kcal. *Significant difference from baseline, P ≤ 0.05.
A: mean activity measured across the 24-h day by accelerometer in 3 monkeys (symbols) at baseline, before monkeys started running on the treadmill 5 days/wk, and mean activity during the 23 h/day when monkeys were not running at the end of 12 wk of running (mean activity shown by bars). B: percent increase in total activity measured across the 24-h day at the end of 12 wk of running compared with the baseline period.