Numerous studies have detailed the extensive conservation of developmental signaling pathways between the model system, Drosophila melanogaster, and mammalian models, but researchers have also profited from the unique and highly tractable genetic tools available in this system to address critical questions in physiology. In this review, we have described contributions that Drosophila researchers have made to mathematical dynamics of pattern formation, cardiac pathologies, how pain circuits are integrated to elicit responses from sensation, and the ways in which gene expression can modulate diverse behaviors and shed light on human cognitive disorders. The broad and diverse array of contributions from Drosophila underscore its translational relevance to modeling human disease.
- dorsal vessel
- TRP channels
- mushroom bodies
- Copyright © 2012, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology