Table 1.

Dose-dependent increase in shortening of ventricular myocytes by CGRP and Iso in adult rat and mouse

Basal 10 pM Basal 100 pM Basal 1 nMBasal 10 nM Basal 100 nM Number of cells
GGRP-induced positive inotropic effect
%Cell shortening 4.6 ± 0.55.6 ± 0.9 4.4 ± 0.4 8.2 ± 0.84.9 ± 0.5 10.1 ± 0.9 4.7 ± 0.510.2 ± 1.0 4.1 ± 0.4 8.8 ± 0.520, 14 rats
%Cell shortening 4.4 ± 0.76.1 ± 1.0 3.9 ± 0.7 9.9 ± 2.14.3 ± 0.8 11.4 ± 1.8 5.0 ± 1.58.5 ± 2.3 14, 7 mice
Basal 1 nM Basal 10 nM Basal 100 nMBasal 1 μM Number of cells
Iso-induced positive inotropic effect
%Cell shortening 4.5 ± 0.68.2 ± 1.1 4.7 ± 0.6 9.1 ± 1.24.5 ± 1.0 10 ± 2.0 4.4 ± 1.014.0 ± 1.6 15, 8 rats
%Cell shortening3.9 ± 0.7 9.9 ± 2.1 4.3 ± 0.811.4 ± 1.8 5.0 ± 1.5 8.5 ± 2.314, 8 mice
  • Values are means ± SE. Iso, isoproteranol; CGRP, calcitonin gene-related peptide.