Table 1.

Arterial blood gases in newborn sheep

BasalHypoxiaRecovery
pHaHLC7.474 ± 0.0137.444 ± 0.0137.429 ± 0.009
HL-FAS7.489 ± 0.0087.479 ± 0.0137.495 ± 0.009
LLC7.404 ± 0.015c7.364 ± 0.022c7.396 ± 0.024
PaO2, mmHgHLC44.0 ± 1.130.4 ± 0.6e48.0 ± 1.3
HL-FAS38.9 ± 1.230.5 ± 0.3e40.5 ± 3.4
LLC82.6 ± 2.6c30.1 ± 0.3e89.0 ± 3.2c
PaCO2, mmHgHLC28.3 ± 0.5d27.9 ± 0.6d26.2 ± 0.9d
HL-FAS33.5 ± 1.8f32.9 ± 1.6f31.2 ± 1.7
LLC38.7 ± 1.238.2 ± 1.434.1 ± 1.3
%Sat Hb, %HLC71.3 ± 1.345.9 ± 1.7e74.5 ± 1.8
HL-FAS67.9 ± 2.450.8 ± 3.3e70.7 ± 3.4
LLC95.5 ± 0.5c50.9 ± 4.0e96.4 ± 0.7c
Hb, g/dlHLC11.7 ± 0.812.0 ± 1.111.5 ± 0.8
HL-FAS12.2 ± 0.811.8 ± 1.112.0 ± 0.8
LLC10.8 ± 0.511.1 ± 0.410.3 ± 0.4
O2 content, ml O2/dlHLC11.2 ± 0.67.5 ± 0.5e11.4 ± 0.6
HL-FAS10.9 ± 0.68.4 ± 0.7e11.1 ± 0.8
LLC14.2 ± 0.6c7.7 ± 0.8e13.6 ± 0.6c
  • Values are means ± SE taken as basal, hypoxia, and recovery. Highland newborn sheep were treated for 10 days either with fasudil (HL-FAS, n=5) or NaCl 0.9%, highland control (HLC, n=5) and lowland control (LLC, n=5), during an episode of hypoxia. Significant differences at P < 0.05 (ANOVA + Newman-Keuls test) are shown as

  • c LLC vs. all;

  • d HLC vs. all;

  • e Hypoxia vs. Basal and Recovery;

  • f HL-FAS vs. LLC. pHa, arterial pH; PaO2, arterial O2 partial pressure; PaCO2, arterial CO2 partial pressure; %Sat Hb, percent saturation of hemoglobin with oxygen; Hb, hemoglobin concentration.