Table 3.

Did genetic deletion of Calhm1, P2X2+P2X3, SGLT1, or Sur1 alter plasma insulin or blood glucose response to oral stimulation with glucose (experiment 6)?

Signaling proteinBlood MeasurementSource of VariationF RatiodfP Value
Calhm1Plasma insulinTime15.04,52<0.001
Genotype<0.11,130.79
Interaction0.84,520.50
Blood glucoseTime25.74,52<0.0001
Genotype1.71,130.21
Interaction0.44,520.82
P2X2+P2X3Plasma insulinTime12.44,52<0.001
Genotype1.41,130.26
Interaction0.54,520.72
Blood glucoseTime32.94,52<0.001
Genotype1.41,130.26
Interaction5.04,52<0.002
SGLT1Plasma insulinTime10.14,72<0.001
Genotype0.71,180.43
Interaction0.94,720.44
Blood glucoseTime14.64,72<0.001
Genotype25.31,18<0.001
Interaction10.14,72<0.001
Sur1Plasma insulinTime8.74,84<0.001
Genotype3.71,210.07
Interaction4.84,84<0.002
Blood glucoseTime68.34,84<0.001
Genotype82.21,21<0.001
Interaction23.34,84<0.001
  • Actual data are presented in Fig. 9. We performed mixed-model ANOVAs, separately for each transduction protein and blood measurement. In each case, time was a within factor and genotype a between factor.