Table 2.

In vivo structural and functional cardiac parameters measured by echocardiography in Sham and RUPP rats at 8 wk postpartum

Sham (n = 9)*RUPP (n = 19)*P Value
Heart weight, g0.85 ± 0.070.89 ± 0.070.185
Structural
    LV mass, mg789 ± 166812 ± 1410.707
    LV mass/body weight, mg/g2.9 ± 0.73.0 ± 0.50.646
    LVPWd, mm1.7 ± 0.51.7 ± 0.40.886
    LVPWs, mm2.6 ± 0.62.3 ± 0.50.274
    LVAWd, mm1.5 ± 0.31.6 ± 0.30.408
    LVAWs, mm2.5 ± 0.22.5 ± 0.30.741
    LVIDd, mm7.25 ± 0.647.12 ± 0.610.624
    LVIDs, mm4.34 ± 0.864.63 ± 0.540.278
    LV VOLd, μl278.8 ± 51.9273.6 ± 36.70.761
    LV VOLs, μl89.3 ± 38.3100.9 ± 26.00.355
Functional
    HR, beats/min337 ± 19342 ± 230.613
    CO, ml63.7 ± 8.959.1 ± 11.10.300
    Mean aortic velocity, mm/s743 ± 167982 ± 3640.115
    Peak aortic velocity, mm/s1338 ± 3321735 ± 5930.115
    Peak aortic gradient7.6 ± 3.610.5 ± 5.80.235
    MV E, mm/s904 (741–927)861 (602–912)0.667
    MV A, mm/s659 (604–807)653 (508–737)1.000
    MV E/A1.3 ± 0.21.3 ± 0.10.957
    IVRT, ms19.2 ± 5.322.0 ± 6.30.318
    IVCT, ms21.1 ± 7.223.9 ± 7.30.415
  • Data are means ± SD or medians (25–75 percentile). LV, left ventricle; LVPWd and LVPWs, left ventricular posterior wall during end diastole and end systole; LVAWd and LVAWs, left ventricular anterior wall during end diastole and end systole; LVIDd and LVIDs, left ventricular internal diameter end diastole and end systole; LV VOLd and LV VOLs, left ventricular volume during diastole and systole HR, heart rate; CO, cardiac output; MV E, peak mitral valve (MV) early filling; MV A, peak MV active filling; MV E/A, MV early-to-active filling ratio; IVRT, isovolumetric relaxation time; IVCT, isovolumetric contraction time

  • * Total number of rats in each group, all parameters were successful in at least 70% of the animals.