Table 1.

Metabolic, hormonal, and GFR data for control and insulin-clamped rats

2-h Fasted2-h Meal5-min Glucose Bolus
CIC-HighCIC-HighCIC-High
Body wt, g383 ± 4379 ± 4N/AN/AN/AN/A
Food intake, g/day or g/4 h16 ± 125 ± 2*6.2 ± 0.56.1 ± 1.2N/AN/A
Water consumption, ml/day or ml/4 h6 ± 229 ± 3*4 ± 14 ± 1N/AN/A
Urinary antidiuretic hormone excretion, pg/hN/AN/A126.9 ± 22.976.8 ± 9.3*79.6 ± 16.6123.7 ± 21.2
Plasma Na, mmol/l138.1 ± 2.8138.0 ± 1.2136.0 ± 1.9137.0 ± 1.4140.1 ± 1.3144.4 ± 1.9
Plasma K, mmol/l4.9 ± 0.44.6 ± 0.14.6 ± 0.14.8 ± 0.25.9 ± 0.35.4 ± 0.4
GFR, ml/min3.1 ± 0.33.2 ± 0.1N/AN/AN/AN/A
PRA, ng ANG I·ml−1·h−11.72 ± 0.421.70 ± 0.431.22 ± 0.370.90 ± 0.51N/AN/A
  • Values are means ± SE.2-h Fasted data were collected at the end of, or over, a 24-h period. 2-h Meal and 5-min Glucose Bolus data were collected during each respective acute test. C, control rats; IC-High, insulin-clamped rats; Na, sodium; K, potassium; GFR, glomerular filtration rate; PRA, plasma renin activity; ANG I, angiotensin I; N/A, not applicable.

  • * P < 0.05.