Table 1.

Demographic information and cardiometabolic end points for Non-Rad-CTL, Rad-CTL, and Rad-DM rhesus macaques

GroupP Value
Non-Rad-CTLRad-CTLRad-DMOverallRadiation effectDiabetes effect
Age, yr12.6 ± 0.413.1 ± 0.913.9 ± 1.00.52N/AN/A
Age at exposure, yrN/A4.24 ± 0.675.04 ± 0.760.44N/AN/A
Radiation dose, GyN/A7.14 ± 0.216.98 ± 0.200.57N/AN/A
Time since irradiation, yrN/A8.9 ± 0.29.0 ± 0.30.76N/AN/A
Body wt, kg14.1 ± 1.3a8.9 ± 0.6b14.2 ± 0.9a<0.0010.100.08
Waist circumference, cm45.3 ± 3.1a,b35.1 ± 2.5a46.7 ± 3.6b0.030.310.13
Blood glucose, mg/dl62 ± 6a66 ± 4a237 ± 31b<0.0010.02<0.001
Insulin, µIU/ml35.3 ± 9.6a,b14.8 ± 5.0a62.7 ± 31.3b0.020.370.09
Hemoglobin A1c, %4.5 ± 0.8a4.6 ± 0.7a9.5 ± 0.7b<0.0010.110.0002
Blood TG, mg/dl45.6 ± 3.7b37.0 ± 2.9b154.1 ± 26.5a<0.0010.35<0.001
HDL cholesterol, mg/dl72.9 ± 4.4a,b78.8 ± 4.3a57.1 ± 5.8b0.020.550.005
Systolic blood pressure, mmHg139.9 ± 7.5153.1 ± 13.4141.5 ± 10.10.690.580.72
Diastolic blood pressure, mmHg73.8 ± 3.472.7 ± 5.470.0 ± 3.70.800.610.51
  • Values are means ± SE. Non-Rad-CTL, nonirradiated nondiabetic, Rad-CTL, irradiated nondiabetic, Rad-DM, irradiated type 2 diabetic; TG, triglycerides. Different superscripted letters (a, b) indicate significant difference between groups (P < 0.05).